Effect of body weight on cytokine response to anti-tubercular therapy in patients with HIV infection and tuberculosis

Venkata Nagesh Ivaturi, Sashindran V Kumar, Anurag Sonkhle

Aim : To assess the role of malnutrition on the cytokine response to anti - tubercular therapy (ATT) in HIV-TB Objectives: a)To assess the effect of BMI on cytokine levels prior to starting ATT. b) To assess the effect of BMI on cytokine levels after intensive phase of ATT. c) To determine if nutritional status has a role in cytokine response to ATT (i.e. change in levels) Conclusion: In our study anti inflammatory cytokines IL- 10 and IL-4 at the baseline as well as after two months of ATT therapy are slightly higher than that of individuals with normal BMI. Interferon γ levels were reduced from initial stage to 02 months of ATT therapy