We study what immunohistochemical and genetic alterations of ccRCC (using MLPA) are associated with tumor prognosis and aggressiveness. An analytical study was done with 57 patients underwent radical and partial nephrectomy, where we found that CAIX and tumor size were associated with worse Fuhrman grade. Certain genetic mutations (CDKN2A, BRCA1 and 2, p53, APC, MDM2, WT1) were associated with worst prognosis and death.
